Leptospirosis among hospitalized febrile patients in northern Tanzania |
| |
Authors: | Biggs Holly M Bui Duy M Galloway Renee L Stoddard Robyn A Shadomy Sean V Morrissey Anne B Bartlett John A Onyango Jecinta J Maro Venance P Kinabo Grace D Saganda Wilbrod Crump John A |
| |
Institution: | Department of Medicine and Department of Pathology, Duke University Medical Center, Durham, NC, USA. |
| |
Abstract: | We enrolled consecutive febrile admissions to two hospitals in Moshi, Tanzania. Confirmed leptospirosis was defined as a ≥ 4-fold increase in microscopic agglutination test (MAT) titer; probable leptospirosis as reciprocal MAT titer ≥ 800; and exposure to pathogenic leptospires as titer ≥ 100. Among 870 patients enrolled in the study, 453 (52.1%) had paired sera available, and 40 (8.8%) of these met the definition for confirmed leptospirosis. Of 832 patients with ≥ 1 serum sample available, 30 (3.6%) had probable leptospirosis and an additional 277 (33.3%) had evidence of exposure to pathogenic leptospires. Among those with leptospirosis the most common clinical diagnoses were malaria in 31 (44.3%) and pneumonia in 18 (25.7%). Leptospirosis was associated with living in a rural area (odds ratio OR] 3.4, P < 0.001). Among those with confirmed leptospirosis, the predominant reactive serogroups were Mini and Australis. Leptospirosis is a major yet underdiagnosed cause of febrile illness in northern Tanzania, where it appears to be endemic. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|