| 乙酰胆碱对离体大鼠下丘脑腹内侧核神经元电活动的影响 |
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| 引用本文： | 储祥平. 乙酰胆碱对离体大鼠下丘脑腹内侧核神经元电活动的影响[J]. 江苏大学学报(医学版), 1996, 0(1) |
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| 作者姓名： | 储祥平 |
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| 摘 要： | 在２３个下丘脑脑片上，用玻璃微电极细胞外记录了５０个下丘脑腹内侧核神经元的自发放电单位，观察了乙酰胆碱对它们的作用。当脑片用含乙酰胆碱（１０－７ｍｏｌ／Ｌ）的人工脑脊液灌流后，有１８个单位放电频率明显增加，这种反应可被乙酰胆碱拮抗剂阿托品所阻断。８个单位放电频率明显减少，８个单位放电频率呈双相反应，１６个单位无明显反应。实验结果表明：约１／３的下丘脑腹内侧核神经元能被乙酰胆碱所激活，且这种作用是由Ｍ受体所介导的。
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| 关 键 词： | 乙酰胆碱，下丘脑腹内侧核，阿托品，离休电生理 |
Effects of acetylcholine on the electric activity of ventromedial nuclens neurons of rat hypothalamic slices |
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| Chu Xiangping. Effects of acetylcholine on the electric activity of ventromedial nuclens neurons of rat hypothalamic slices[J]. Journal of Jiangsu University Medicine Edition, 1996, 0(1) |
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| Authors: | Chu Xiangping |
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| Affiliation: | Deljartment of Physiology |
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| Abstract: | Hypothalamic slices were ptepaired with a vibratome.The spontaneous discharge of 50vcntromedial nucleus(VMN) neurons was recorded by glass mioroclectrode from 23 such sliees,and effects of acetylcholine(Ach) on spontaneous discharge were observed.After per-fusing the brain sliceswith artificial cerebrospinal fluid containing Ach(10-7mol/L) for 3 min,discharge rate of 18 units was significantly increased,this responsc was blocked by muscular acetylcholine receptor antagonist-atropine.The discharge of 8units were deereased.8 units showed biphasic effeets,and 16 units were non-responsive.The cxpcrimcntal results suggest that about 1/3 of ventromcdial nuclcus neurons can be activated by Ach via the act ivat ion of Aeh receptors.This effects can be mcdiated by M type receptor. |
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| Keywords: | Ach Ventromedial nucleus of hypothalamus Atropine In vitro electrophysiology |
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