健力颗粒对运动性疲劳免疫功能影响的实验研究

目的：通过实验研究,观察健力颗粒对运动性疲劳免疫功能的影响,探讨其抗运动性疲劳的作用机制。方法：采用SPF级健康SD大鼠,随机分为正常对照组、阳性对照组（三勒浆组）、健力颗粒低剂量、中剂量及高剂量组。游泳法建立慢性力竭性运动性疲劳模型,摘除大鼠眼球取血,检测动物T淋巴细胞增殖能力,NK细胞活性及IL-1,IL-6的活性。结果：与正常对照组相比,健力颗粒各剂量组和三勒浆组能增强T细胞的增殖活力,使NK细胞杀伤活性I、L-1活性以及IL-6的含量显著提高（P〈0.05,P〈0.01）。健力颗粒高剂量组作用优于三勒浆组（P〈0.05）。结论：明显提高抗疲劳能力。健力颗粒能改善实验大鼠免疫功能,具有较好的抗运动性疲劳作用。

Experimental study on effect of JianLiKeLi on immune function of rat with exercise-induced fatigue

Objective: To observe the effect of JianLiKeLi(JLKL) on immune function of rat with exercise-induced fatigue and discuss the mechanism of its anti-fatigue.Methods: SPF healthy SD rats were randomly divided into five groups:the control group,the SLJ group,the low dose of JLKL group,middle dose of JLKL group and high dose of JLKL group.The chronic fatigue model was established by exhaustive swimming.Eyeball was removed to collect blood,and the ability of T lymphocyte proliferation,NK cells,IL-1 and IL-6 were tested.Results: Compared with the control group,T cells proliferation in the high and middle dose of JKLL groups increased,the activities of NK cells,IL-1 and IL-6 in the three doses of JLKL groups and the SLJ group were all higher(P<0.05,P<0.01).High dose of JLKL group had better effect than the SLJ group(P<0.05).Conclusion:JLKL can obviously improve the immune function of rats with exercise-induced fatigue. It has better effect of resisting exercise fatigue.