妊娠期肝内胆汁淤积症胎儿监测的临床研究进展

妊娠期肝内胆汁淤积症(ICP)是妊娠期特有疾病,主要表现为孕妇无皮损性瘙痒、肝功能异常,并可导致新生儿黄疸、凝血功能异常等。ICP对母体的危害较小,对胎儿危害极大,可导致胎儿早产、羊水胎粪污染及胎儿窘迫,甚至胎死宫内(IUFD)等不良围生儿结局。该病导致的胎儿死亡多为突然发生,临床上难以预测。而加强产前及产时胎儿监测,仍是预防IUFD的主要措施,故对ICP胎儿的监测越来越受到产科临床的重视。

Clinical Research Progress on Fetal Monitoring of lntrahepatic Cholestasis of Pregnancy

Intrahepatic cholestasis of pregnancy(ICP) is a pregnancy-specific disease with the main clinical manifestations of itching, liver disfunction, and so on. ICP can lead to jaundice, coagulation abnormality. ICP has less harmful to the mother than that to the fetus, it can lead to adverse perinatal outcomes, such as premature, meconium staining, fetal distress, even intrauterine fetal death(IUFD). Antenatal and intrapartum fetal monitoring are still the main measures to prevente IUFD, obstetricians should pay more and more attention on ICP fetal monitoring.