| 汉防己甲素对实验性葡萄膜炎的治疗作用及机制 |
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| 引用本文： | 肖继皋,吴树扬,王育良,张民英,李晶阁. 汉防己甲素对实验性葡萄膜炎的治疗作用及机制[J]. 中华眼底病杂志, 1994, 10(3): 149-152 |
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| 作者姓名： | 肖继皋 吴树扬 王育良 张民英 李晶阁 |
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| 作者单位： | 南京医科大学药理学教研室，南京中医学院附属医院眼科 |
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| 摘 要： | 用牛血清白蛋白诱发了家兔实验性葡萄膜炎。汉防己甲素(Tet 50 mg/kg/d ip)和地塞米松（Dex 5 mg/kg/d ip）治疗8天，能显著降低眼部炎症反应、房水蛋白含量、血清免疫复合物和外周T淋巴细胞转化率。停止给药后4天,Dex组房水蛋白和血清免疫复合物再度升高。Tet组虽有升高，但比Dex组明显为低。病理学检查发现Tet组脉络膜炎症比对照组明显为轻。结果表明，Tet抑制实验性葡萄膜炎，除了其抗炎作用外，还与其抑制体液和细胞免疫反应有关。（中华眼底病杂志，1994，10：149-152）
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| 关 键 词： | 葡萄膜炎 免疫反应 汉防己甲素 |
| 收稿时间： | 1994-05-20 |
THERAPEUTIC ACTIONS AND MECHANISM OF TETRANDRINE ON EXPERIMENTAL UVEITIS |
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| Xiao Jigao,Wu Shuyang,Wang Yuliang,et al.. THERAPEUTIC ACTIONS AND MECHANISM OF TETRANDRINE ON EXPERIMENTAL UVEITIS[J]. Chinese Journal of Ocular Fundus Diseases, 1994, 10(3): 149-152 |
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| Authors: | Xiao Jigao Wu Shuyang Wang Yuliang et al. |
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| Affiliation: | Dept of Pharmacology,Nanjing Medical University, 210029 |
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| Abstract: | Experimental uveitis was induced in rabbits by bovine serum albumin. Ocular inflammation,protein content of aqueous humor,T lymphocyte transformation and serum circulating immune complex were reduced markedly after the treatment of tetrandrine (Tet, 50mg/kg/d,ip)and dexamethasone(Dex, 5mg/kg/d,ip)for 8 days. Four days after withdrawal of Tet and Dex the protien content of the aqueous humor and serum eiucrlating immune complexes rose again,but these parameters in Tet group is lower than that in Dex group. The pathologicalstudy showed that inflammation of choroid in Tet treated group was lighter than that in untreated group. These results suggest that Tet is an effective inhibitory agent on bovine serum albumin-induced experimental uveitis. Its mechanism may be related to the suppression of cellular and humoral immune function aside from antiinflammation.（Chin J Ocul Fundus Dis,1994,10:149-152） |
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| Keywords: | uveitis immunofunction tetrandrine |
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