前列腺钙化灶分布在初筛前列腺癌中的作用

正钙化是前列腺结节中的常见现象,在超声引导下经直肠前列腺穿刺过程中经常可以观察到患者前列腺钙化改变,在前列腺根治标本中,病理医师常发现前列腺钙化灶的存在,然而关于前列腺钙化灶与前列腺疾病关系仍不明确~(1-2])。既往研究发现,前列腺钙化灶与良性前列腺增生及慢性前列腺炎存在一定关系,也有一些研究提示,前列腺炎症及钙化可能提示前列腺恶性肿瘤改变。前列腺癌往往好发于前列腺外周带,而前列腺增生起源于移行带,不同部位的

The Prevalence of Prostatic Calcification in peripheral zone can be predictors of prostate cancer

OBJECTIVE: To evaluated the prevalence of Prostatic Calcification(PC)during transrectal ultrasound (TRUS) and correlate the ultrasonographic patterns with histological findings METHOD: A prospective study of men undergoing TRUS and prostatic biopsy was designed; Representative images of the calcification in the sagittal and transverse planes were captured. PC were classified according to zone distribution into the gland: transitional zone, interface zone, and peripheral zone. TRUS findings were correlated with histologic data. RESULT: A total of 352 patients (44.33%) had prostate cancer, 203 patients (25.57%) inflammation, and 239 patients (30.10%) had benign pathology. Interface calcification was present in 42.9% of patients. Peripheral or transitional zone calcification was unusual (6.29% and 8.69%, respectively). Of the peripheral zone calcification group patients, 68% had cancer on histology examination (P<0 .05).CONCLUSION: the prevalence of PC in peripheral zone appears to be strongly associated with prostate cancer; but was not associated with higher Gleason grade among these patients.