| 狼疮性肾炎患儿他克莫司联合伏立康唑的个体化药学监护 |
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| 引用本文： | 刘红霞,姜志虎,李志玲,孙华君. 狼疮性肾炎患儿他克莫司联合伏立康唑的个体化药学监护[J]. 儿科药学杂志, 2018, 24(11): 39-41 |
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| 作者姓名： | 刘红霞 姜志虎 李志玲 孙华君 |
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| 作者单位： | 上海市儿童医院,上海交通大学附属儿童医院,上海 200062 |
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| 摘 要： | 目的:探讨CYP3A5基因型和伏立康唑对他克莫司用药剂量的影响。方法:临床药师通过对1例狼疮性肾炎患儿进行药学监护,根据CYP3A5基因型对他克莫司初始用药剂量进行估算,联用伏立康唑后,对他克莫司用药剂量进行调整。结果:临床药师通过药学监护,给予个体化的用药建议,提高了患儿用药的安全性和有效性。结论:临床药师在临床个体化给药方案的制定中发挥着积极的作用。
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| 关 键 词： | 药学监护 他克莫司 伏立康唑 |
Individualized Pharmaceutical Care of Tacrolimus Combined with Voriconazole for Children with Lupus Nephritis |
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| Liu Hongxi,Jiang Zhihu,Li Zhiling,Sun Huajun. Individualized Pharmaceutical Care of Tacrolimus Combined with Voriconazole for Children with Lupus Nephritis[J]. Journal of Pediatric Pharmacy, 2018, 24(11): 39-41 |
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| Authors: | Liu Hongxi Jiang Zhihu Li Zhiling Sun Huajun |
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| Affiliation: | Shanghai Children''s Hospital, Children''s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200062, China |
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| Abstract: | Objective: To probe into the effects of CYP3A5 genotype and voriconazole on the dosage of tacrolimus. Methods: Clinical pharmacists provided pharmaceutical care for a child with lupus nephritis, and estimated the initial dosage of tacrolimus according to CYP3A5 genotype. After the drug combination of voriconazole, the dosage of tacrolimus was adjusted. Results: Through the pharmaceutical care, individualized medication recommendations were given to improve the safety and effectiveness of the medication. Conclusion: Clinical pharmacists play an active role in the formulation of individualized clinical dosage regimens. |
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| Keywords: | pharmaceutical care tacrolimus voriconazole |
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