中药穴位贴敷联合西药化疗治疗初治肺结核的临床疗效观察

目的:通过中药穴位贴敷联合西药化疗干预,评价穴位贴敷疗法在初治肺结核治疗中的有效性及协同作用、安全性。方法:将100例初治肺结核患者随机分为对照组和观察组,对照组予异烟肼联合利福平、吡嗪酰胺及乙胺丁醇常规化疗,观察组在西药化疗基础上联用中药穴位贴敷治疗,两组患者均连续治疗8周(强化期)。观察治疗前后的临床症状改善情况,并评价临床疗效;检测外周血CD4~+T及CD8~+T细胞绝对数改变,记录外敷的不良反应情况。结果:治疗后,两组患者的中医临床症状均得到明显改善,且观察组的症候疗效优于对照组(P0.05);两组患者治疗后的CD4~+T细胞绝对数均显著增加、CD8~+T细胞绝对数显著减低(P0.05),且观察组的改变明显大于对照组(P0.05)。未发现皮肤有明显的不良反应。结论:中药穴位贴敷联合常规西药化疗可有效改善初治肺结核患者的临床症状,改善细胞免疫状态,且安全有效。

Clinical efficacy observation of acupoint application with Chinese medicine combined

  Objective: To evaluate the efficacy, synergistic effect and safety of acupoint application therapy in the treatment of initial pulmonary tuberculosis through acupoint application of Chinese medicine combined with chemotherapy of western medicine intervention.   Methods:One hundred cases of initial pulmonary tuberculosis were randomly divided into the control group and the observation group. The patients in the control group were treated with conventional chemotherapy including isoniazid combined with rifampicin, pyrazinamide and ethambutol. The patients in the observation group were treated with acupoint application of Chinese medicine on the basis of western medicine chemotherapy. Both groups were treated for continous 8 weeks (intensive period). The improvement of clinical symptoms before and after treatment was observed, and the clinical efficacy was evaluated. The absolute numbers of CD4⁺T cells and CD8⁺T cells in peripheral blood were detected, and the adverse reactions of external application were recorded.   Results: After treatment, the clinical symptoms of the two groups were significantly improved, and the syndrome efficacy of the observation group was better than that of the control group (P<0.05); the absolute numbers of CD4⁺T cells in the two groups were significantly increased, the absolute numbers of CD8⁺T cells were significantly decreased (P<0.05), and the changes of the observation group were significantly greater than those of the control group (P<0.05). No obvious adverse reactions were found in the skin.   Conclusion: Acupoint application of Chinese medicine combined with routine western medicine chemotherapy can effectively improve the clinical symptoms and the cellular immune status of initial pulmonary tuberculosis patients, which is safe and effective.