Impaired endothelium-dependent and neurogenic relaxation of corpus cavernosum from diabetic rats: improvement with L-arginine |
| |
| Authors: | S. Gür B. Öztürk S. T. Karahan |
| |
| Affiliation: | (1) Ankara üniversitesi, Eczacılık Fakültesi, Farmakoloji Anabilim Dalı 06100 Tandoğan, Ankara, Turkey e-mail: sgur@pharmacy.ankara.edu.tr Tel.: +90 312-2126805/253, Fax: +90 312-2131081, TR;(2) Department of Urology, Numune Hospital, Ankara, Turkey, TR;(3) Department of Anatomy, Faculty of Medicine, Ankara University, Ankara, Turkey, TR |
| |
| Abstract: | This study describes the relaxant response to acetylcholine, electrical field stimulation and sodium nitroprusside after contraction by phenylephrine (10−5 M) in corpus cavernosum from control and diabetic rats. The response to acetylcholine (10−9–10−3 M) and electrical field stimulation (0.5–64 Hz) is decreased and can be restored by the addition of nitric oxide synthatase substrate, l-arginine(10−5 M). The response to sodium nitroprusside is not changed in diabetic rats compared to control rats. NADPH-diaphorase staining was enhanced in a diabetic preparation compared to control preparations. The findings suggest a role for the depletion of l-arginine in diabetes mellitus. The enhanced NADPH-diaphorase staining may be due to a deficiency of NOS substrate l-arginine in the endothelium and nerves of diabetic tissues. Received: 27 April 1999 / Accepted: 19 August 1999 |
| |
| Keywords: | Acetylcholine Diabetes mellitus L-arginine Corpora cavernosa |
| 本文献已被 PubMed SpringerLink 等数据库收录！ |
|
