Relationship between in vivo muscle force at different speeds of isokinetic movements and myosin isoform expression in men and women |
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Authors: | H?Gür L?Gransberg D?vanDyke E?Knutsson Email author" target="_blank">L?LarssonEmail author |
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Institution: | (1) , Department of Sports MedicineMedical School of Uludag University, Bursa, Turkey,;(2) , Department of Clinical NeurophysiologyUppsala University Hospital, SE-751 85, Uppsala, Sweden,;(3) , Noll Physiological Research Center, Center for Development and Health GeneticsThe Pennsylvania State University, University Park, Pennsylvania, USA,;(4) , Department of Cellular and Molecular Physiology, Hershey Medical CenterThe Pennsylvania State University, University Park and Hershey, Pennsylvania, USA, |
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Abstract: | In an attempt to explore the relationship between force production during voluntary contractions at different speeds of isokinetic
movement and the myofibrillar protein isoform expression in humans, an improved isokinetic dynamometer that corrects for gravitation,
controls for acceleration and deceleration, and identifies a maximum voluntary activation was used. Muscle torque recordings
were compared at the same muscle length (knee angle) and the torque was calculated as the average torque at each angle over
a large knee angle range (75°–25°) to reduce the influence of small torque oscillation on the calculated torque. Muscle torque
at fast (240° s−1) versus slow (30° s−1) speeds of movement, torque normalized to muscle cross-sectional area (specific tension), and absolute torque at fast speeds
of movement were measured in 34 young healthy male and female short-, middle-, and long-distance runners. The relationship
between the different measures of muscle function and the expression of myosin heavy chain (MyHC) isoforms using enzyme–histochemical
and electrophoretic protein separation techniques were investigated. A significant correlation between the 240° s−1 vs 30° s−1 torque ratio and the relative area of the type II fibers and type II MyHC isoforms were observed in both the men (r=0.74;P<0.001) and the women (r=0.81; P<0.05). Thus, the present results confirm a significant relationship between in vivo human muscle function and the MyHC isoform
expression in the contracting muscle.
Electronic Publication |
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Keywords: | Isokinetic Myosin heavy chain isoforms Gender Human skeletal muscle |
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