上皮性卵巢癌术前血清CA125水平与临床病理特征及患者预后的关系

目的 探讨上皮性卵巢癌患者术前血清CA125水平与临床病理特征及患者预后的关系.方法 回顾性分析榆林市第一医院和靖边县人民医院于2008年1月至2016年6月间收治的72例上皮性卵巢癌患者的临床资料,选择同期健康体检的健康妇女70例纳入对照组;比较两组受检者血清CA125水平;比较不同病理类型、是否绝经、腹腔积液、淋巴结转移、临床病理分期患者术前血清CA125水平;根据不同预后将患者分为死亡组(n=20)和存活组(n=52),比较两组术前血清CA125水平.结果 上皮性卵巢癌患者术前血清CA125水平为(144.5±43.4)U/mL,明显高于对照组的(11.5±5.4)U/mL,差异有统计学意义(P<0.05);浆液性癌者、有腹腔积液者、临床病理分期(Ⅲ+Ⅳ)者的术前血清CA125水平均明显高于非浆液性癌者、无腹腔积液者及临床病理分期(Ⅰ+Ⅱ)者,差异均有统计学意义(P<0.05);死亡组患者术前血清CA125水平为(179.5±49.4)U/mL,明显高于存活组的(126.4±31.2)U/mL,差异有统计学意义(P<0.05).结论 术前血清CA125水平与上皮性卵巢癌的临床病理特征关系密切,在患者的预后评估中具有重要价值.

Relationship between preoperative serum CA125 and clinicopathological features and prognosis in patients with epithelial ovarian cancer

Objective To investigate the relationship between preoperative serum CA125 levels and clinico-pathological features and prognosis in patients with epithelial ovarian cancer. Methods Clinical data of 72 patients with epithelial ovarian cancer patients who were treated in Yulin First Hospital and Jingbian People's Hospital from Janu-ary 2008 to June 2016 was analyzed retrospectively, and 70 healthy women were included into the control group. The se-rum CA125 level of the two groups were compared. Preoperative serum CA125 levels were compared between patients with different pathological types, menopause, ascites, lymph node metastasis, and clinicopathologic stage. According to the different prognosis, the patients were divided into death group (n=20) and survival group (n=52), and preoperative se-rum CA125 levels were compared between the two groups. Results The preoperative serum CA125 level of epithelial ovarian cancer was (144.5 ± 43.4) U/mL, which was significantly higher than (11.5 ± 5.4) U/mL in the control group (P<0.05). The preoperative serum CA125 levels in patients with serous carcinoma, ascites, clinical pathological stage (Ⅲ+Ⅳ) were significantly higher than those of the patients with non-serous carcinoma, no ascites and clinical pathological stage (Ⅰ+Ⅱ) (P<0.05). The preoperative serum CA125 level in death group was (179.5±49.4) U/mL, which was signifi-cantly higher than (126.4±31.2) U/mL in the survival group (P<0.05). Conclusion Preoperative serum CA125 level is closely related to the clinicopathological characteristics of epithelial ovarian cancer, which play an important role in the prognosis evaluation of patients with epithelial ovarian cancer.