基于细胞色素P450酶的药物相互作用机制探讨

细胞色素P450酶是药物体内代谢的关键酶,药物合用时可能因与同一种代谢酶的相互作用,导致药物在体内的处置过程发生改变.本文旨在探讨常见的细胞色素P450酶相关药物相互作用类型和其机制,为临床联合用药的合理、安全、有效提供依据.

Review of Drug Interactions Mechanism Based on Cytochrome P450s

Cytochrome P450s are the key enzymes during drug metabolism.Combinat ion of drugs might lead to changes of pharmacokinetics due to interactions on th e same enzyme.This article aims to explore common types and mechanism of cytoch rome P450s-related drug interactions,which provides the basis of reasonable,safe and effective drug combinations in clinics.