先天缺牙相关基因的研究进展

先天缺牙属于牙齿发育异常中的数目异常,是一种临床常见疾病,对患者的咀嚼功能、美观、发音及心理健康都有着严重影响.根据是否伴发全身症状,可将先天缺牙分为综合征性先天缺牙与非综合征性先天缺牙.先天缺牙的致病因素包括环境因素和遗传因素.随着人类遗传学及分子生物学的迅猛发展,遗传因素受到越来越多的重视,发现新的相关基因以及新的突变位点已成为目前基因研究的一个主要方向.本文就近年来先天缺牙相关基因的研究进展做一综述.

Research progress on gene involved in tooth agenesis

Tooth agenesis refers to tooth absence during tooth development, and it is a common disease in clin-ic. The disease affects the chewing function, the pronunciation, appearance and mental health severely. It can be divided into syndromic tooth agenesis and non-syndromic tooth agenesis according to whether it is accompanied by other symp-toms of tissues or organs. The pathogenic factors include environmental factors and genetic factors. With the rapid devel-opment of human genetics and molecular biology, the genetic factors are gaining more and more attention. The discovery of related gene mutations has become a focus of gene research in recent years, and at the same time there are new related genes have been found. The research progress of the tooth agenesis related genes are reviewed in this paper.