筋骨草属植物中二萜类成分的化学及药理活性研究进展

唇形科筋骨草属植物的主要成分是新克罗烷型和松香烷型二萜,新克罗烷型二萜具有C-4,C-9位侧链取代基类型多变的结构特点,松香烷型二萜结构中多存在一个或多个酚羟基,筋骨草属植物的二萜类成分具有抗炎,抗菌,抗肿瘤,降压以及昆虫拒食等广泛药理活性.本文对筋骨草属植物的萜类成分及其药理活性进行综述,为该类化合物的后续研究提供参考.

Progress on Diterpenoids and Their Biological activities of the Genus Ajuga

Therearemany important medicinal plants in Genus Ajuga (Labiatae.),and their medicinal potential is due to the presense of various pharmacologic ally active compounds,especially affluent neo-clerodane and abietane diterpeno ids with activities such as antifeedant,anti-inflammatory,antibacterial,an titumor as well as antihypertensive.The neo-clerodane diterpenoid′s structure characteristics are the multilingualsubstitutes at positions4 and 9.In additi on,phenolic hydroxyl groups always exist in the structure of abietane diterpen oids.The aim of this review article was to gather information about diterpenoi ds in Ajuga and their biological activities which has been published nearly twen ty years for further study and ploit.