| 响应面法优化桂龙凝胶膏剂提取工艺 |
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| 引用本文： | 黄君丽,詹利之,李智勇,谭梅英.响应面法优化桂龙凝胶膏剂提取工艺[J].海峡药学,2017,29(2). |
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| 作者姓名： | 黄君丽 詹利之 李智勇 谭梅英 |
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| 作者单位： | 1. 广州市胸科医院药剂科 广州 510095;2. 广州中医药大学热带医学研究所 广州 510405;3. 广东省第二中医院广东省中医药工程技术研究院 广州 510095;4. 广东省省第二中医院药学部 广州 510095 |
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| 基金项目： | 广东省中医药局科研课题 |
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| 摘 要： | 目的 优选桂龙凝胶膏剂的提取工艺.方法 采用响应面法,以乌头总碱提取率和干膏得率为指标进行试验,考察乙醇浓度、乙醇用量、提取时间对桂龙凝胶膏剂提取工艺的影响.结果 最佳提取工艺为：乙醇浓度为81.48%,乙醇用量为15.94倍,提取时间为65.62min,提取2次,乌头总碱提取率和干膏得率分别为0.1372mg·g-1和26.16%.结论 优选的提取工艺稳定可行,为桂龙凝胶膏剂的制备提供了实验依据.
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| 关 键 词： | 桂龙凝胶膏剂 提取工艺 响应面法 |
Optimization of Extraction Technology Based on Response Surface Methodology for Guilong Cataplasm |
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| HUANG Jun-li,ZHAN Li-zhi,LI Zhi-yong,TAN Mei-ying.Optimization of Extraction Technology Based on Response Surface Methodology for Guilong Cataplasm[J].Strait Pharmaceutical Journal,2017,29(2). |
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| Authors: | HUANG Jun-li ZHAN Li-zhi LI Zhi-yong TAN Mei-ying |
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| Abstract: | OBJECTIVE To optimize the extraction process of Guilong Cataplasm.METHODS WTBZ The influential factors were ethanol concentration,solvent volume and extraction time.The evaluating indicator was the extraction rate of total a conitum alkaloids and dry extract yield.Response surface methodology(RSM) was used to optimize the process.RESULTS The optimum conditions o f extraction we re 81.48% ethanol,15.94 volume folds of solvent and 65.62 min for two extrac tion.CONCLUSION The optimized extraction process is stable a nd feasible,which provides a scientific reference for the preparation of Guilong Cataplasm. |
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| Keywords: | Guilong Cataplasm Extraction technology Responses surface methodology |
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