| 复方仙草胶囊生产工艺中三七提取工艺的优化 |
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| 引用本文： | 黄蓓,韦柳妮.复方仙草胶囊生产工艺中三七提取工艺的优化[J].海峡药学,2017(3). |
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| 作者姓名： | 黄蓓 韦柳妮 |
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| 作者单位： | 1. 广西中医药大学附属瑞康医院 南宁 530011;2. 桂林医学院 桂林 541001 |
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| 基金项目： | 广西卫生厅中医药医院制剂类课题"复方仙草胶囊的研制" |
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| 摘 要： | 目的 优选复方仙草胶囊生产工艺中三七的最佳提取工艺.方法HT6K采用紫外分光光度法测得提取液中三七总皂苷的含量为考察指标,对提取方法、提取溶剂、提取前浸泡时间进行了单因素考察,再通过正交试验考察提取溶剂浓度、提取时间、提取次数、提取溶剂用量对三七提取工艺的影响.结果 最佳提取工艺条件为:选用70%乙醇,乙醇用量为药材的10倍,浸泡30min,加热回流3次,1次1.5h.HT5"H结论 优选的工艺稳定可行,得率高,操作简便,适合工业生产,为复方仙草胶囊的进一步开发生产提供依据.
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| 关 键 词： | 三七 提取工艺 正交实验 三七总皂苷 |
Optimization of Extraction Process for Radix Notoginseng in Productive Technology of Compound Xiancao Capsules |
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| HUANG Bei,WEI Liu-ni.Optimization of Extraction Process for Radix Notoginseng in Productive Technology of Compound Xiancao Capsules[J].Strait Pharmaceutical Journal,2017(3). |
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| Authors: | HUANG Bei WEI Liu-ni |
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| Abstract: | OBJECTIVE To optimize process extraction of Radix Notoginseng i ncompound Xiancao capsules.METHODS Using ultraviolet spectroph otometry for influence of extraction method,extraction solvent and soak time,w ere evaluated in single factor tests.Orthogonal test was adopted to investigate effects of the concentration and volume of ethanol,extraction time and times o n extraction technology of Radix Notoginseng with yield of panax notoginseng sap onins as evaluation index.RESULTS Optimum extraction conditi ons were as follows:10 times of 70% ethanol,extracted for 3 times,each time f or 1 hour.CONCLUSION This optimized process was stable and fea sible,suitable for industrial production,showed higher yield of panax notogins eng saponins and it can provide the references for compound Xiancao Capsule for its further investigation. |
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| Keywords: | Radix Notoginseng Extraction process Orthogonal te st Panax notogingseng saponins |
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