乳腺癌组织中EZH2及p53蛋白表达及其临床意义

目的 研究乳腺癌组织中果蝇zeste基因增强子同源物2(EZH2)及p53蛋白的表达及临床意义.方法 选择从2016年1~10月在青海大学附属医院诊治的乳腺癌患者40例纳入本次研究,将40例患者术区所取的乳腺癌组织记为观察组,另取同期在医院治疗的40例纤维瘤患者的手术切除组织记为对照组,比较乳腺不同组织中EZH2及p53蛋白的表达,分析乳腺癌组织中EZH2及p53蛋白的表达与其病理情况的关系,以及乳腺癌组织中EZH2与p5蛋白表达的相关性.结果 乳腺癌组织中EZH2及p53蛋白的阳性率分别为52.50%、47.50%,均明显高于纤维瘤组织的20.00%和15.00%,差异均有统计学意义(P<0.05).乳腺癌组织中EZH2及p53蛋白的阳性表达与有淋巴结转移及分子亚型为Basal-like型有关,差异均有统计学意义(P<0.05);根据Spearman法对相关性分析后发现,乳腺癌组织中EZH2与p5蛋白的阳性表达之间呈正相关(r=0.66,P<0.05).结论 乳腺癌组织中的EZH2及p53蛋白均存在较强的阳性表达,且两者之间的表达呈正相关.

Expression and clinical significance of EZH2 and p53 protein in breast cancer

Objective To study the expression and clinical significance of enhancer of zeste homolog 2 (EZH2) and p53 protein in breast cancer. Methods A total of 40 patients with breast cancer, who admitted to Qinghai Univer-sity Affiliated Hospital from January 2016 to October 2016, were enrolled in this study. The breast cancer tissues col-lected from 40 patients were selected as the observation group, and another 40 patients with tumor resection in the same period were treated as the control group. EZH2 and p53 protein expression in different tissues of breast were compared, and the relationship between the expression of EZH2 and p53 protein in breast cancer tissues and the patho-logical changes, and the relationship between the expression of EZH2 and p53 protein in breast cancer tissues were an-alyzed. Results The positive rates of EZH2 and p53 protein in breast cancer tissues were 52.50% and 47.50%, re-spectively, which were significantly higher than 20.00%and 15.00%in fibroma tissue (all P<0.05). The positive ex-pression of EZH2 and p53 protein in breast cancer tissues was correlated with lymph node metastasis and molecular subtypes of Basal-like (all P<0.05). According to the correlation analysis of Spearman, it was found that there was a positive correlation between the positive expression of EZH2 and p53 protein in breast cancer tissues (r=0.66, P<0.05). Conclusion The expression of EZH2 and p53 protein in breast cancer tissues is positive, and the expression of the two proteins is positively correlated with each other.