TLR4基因多态性与冠心病易感性相关性Meta分析

目的 研究TLR4(1196C/T)基因多态性与冠心病(CAD)易感性的相关性.方法 计算机检索中国期刊全文数据库(CNKI)、万方数据库、VIP、Pubmed、Web of Science、Science direct以及Wiley online library等数据库,检索TLR41196C>T基因多态性与冠心病相关性的病例对照研究,检索文献均为建库至2016年9月17日.由两名评价员按照纳入与排除标准单独进行文献筛选及资料提取,采用RevMan5.0和Stata11.0软件对纳入的文献进行统计分析.结果 共纳入7篇文献累积7891例冠心病和4018例健康对照.Meta分析结果表明TLR41196C>T基因多态性与CAD风险相关性无统计学意义[等位基因模型T/C:OR=1.02,95%CI(0.77~1.34),P=0.91;显性模型CT+TT/CC:OR=1.01,95%CI(0.76~1.35),P=0.92;隐性模型CC+CT/TT:OR=1.03,95%CI(0.61~1.75),P=0.91;共显性模型CT/CC:OR=1.02,95%CI(0.76~1.36),P=0.91;共显性模型CC/TT:OR=1.05,95%CI(0.62~1.77),P=0.87].各基因模型均无发表偏倚.结论 TLR41196C>T基因多态性与CAD易感性无明显相关性,受纳入文献数量限制,上述结论尚需开展更多研究予以验证.

Association between the 1196(C/T) polymorphism of TLR4 and susceptibility of coronary artery disease: a meta-analysis

Objective To investigate the association between TLR41196(C/T) gene polymorphism and suscep-tibility of coronary artery disease (CAD). Methods The case-control studies of TLR41196 C>T gene polymorphism and susceptibility of coronary artery disease were searched in CNKI, Wanfang database, VIP, Pubmed, Web of Science, Science direct and Wiley online library, which were published up to September 17, 2016. According to the inclusion and exclusion criteria, literature selection and data extraction were performed independently by two reviewers. RevMan5.0 and Stata11.0 software were used for statistical analysis of the literatures. Results A total of 7 studies involving 7891 patients and 4018 controls were analyzed in the study. The results of meta-analysis showed that TLR41196C>T gene polymorphism and CAD risk had no statistically significant correlation (allele model T/C:OR=1.02, 95%CI (0.77-1.34, P=0.91);dominant model CT+TT/CC:OR=1.01, 95%CI (0.76-1.35, P=0.92);recessive model CC+CT/TT:OR=1.03, 95%CI (0.61-1.75), P=0.91;co-dominant model CT/CC:OR=1.02, 95%CI (0.76-1.36, P=0.91);co-dominant model of CC/TT:OR=1.05, 95%CI (0.62-1.77), P=0.87). There was no publication bias in each gene model. Conclusion There is no significant correlation between TLR41196C>T gene polymorphism and CAD susceptibility. Due to the limited number of documents included in the literature, the above conclusions still need to carry out more research to be verified.