鼻息肉组织中IL-9和IL-17及Foxp3的表达及意义

目的：观察鼻息肉组织中IL-9、IL-17及Foxp3的表达，初步探讨Th9、Thl7／Treg细胞失衡在鼻息肉发病机制中的作用。方法：标本取自40例鼻息肉患者鼻息肉组织（鼻息肉组）和20例鼻中隔手术患者的正常中鼻甲黏膜（对照组）。采用免疫组织化学法检测鼻息肉标本和正常中鼻甲黏膜中IL-9、IL-17及Foxp3的表达水平。结果：鼻息肉组织中IL-9、IL-17阳性率分别为75．0％、80．0％，其表达明显高于对照组（阳性率分别为35．0％和50．0％），而Foxp3表达（37．5％）明显低于对照组（80．0％），均P％0．05。结论：IL-9和IL-17因子明显与鼻息肉的发病有关，推测鼻息肉组织中有明显Th9浸润，并存在Thl7／Treg失衡，二者可能在鼻息肉的发病机制中起重要作用。

The expression of IL-9, IL-17 and Foxp3 in nasal polyps

Objective：To observe the expression of IL-9,IL-17 and Foxp3 in nasal polyps,so that to explore the role of Th9,Th17/Treg cells imbalance in pathogenesis of nasal polyposis. Method.. Forty cases of nasal polyps and 20 cases of normal middle turbinate mucosa （controls） were involved in this study. The expression patterns of IL-9,IL-17 and Foxp3 were detected by immunohistochemistry. Result： The positive rates of IL-9 and IL-17 in na- sal polyps tissues were respectively 75.0% and 80.0% ,which were both significantly higher than those in the con- trols（positive rates were 35.0% and 50.0%, respectively）, but the Foxp3 expression was downregulated in nasal polyps tissues（37.5 %） compared to the controls （80.0 %）, P〈0.05 respectively. Conclusion.. The cytokines IL-9 and IL-17 are obviously involved in the occurrence and development of nasal polyposis, suggesting remarkable infil- tration of Th9 and Th17/Treg imbalance exist in nasal polyps, both of which may play important roles in patho- genesis of nasal polyposis.