上海地区2种不同变应原皮肤点刺试剂阳性率的比较

目的：针对同一地区人群,比较2种变应原皮肤点刺试剂阳性率的差别。方法：收集2005-06-2013-02期间上海地区9 233例被拟诊为变应性鼻炎的患者,分别使用阿罗格（阿罗格组）和安脱达（安脱达组）试剂进行皮肤点刺试验（SPT）,分析2种试剂在检测阳性率方面的差异。结果：阿罗格组总体阳性率（62.90%）高于安脱达组（59.68%）,差异有统计学意义（P〈0.01）;粉尘螨、屋尘螨为2组患者的主要变应原,在阿罗格组和安脱达组中粉尘螨的阳性率分别为55.23%和45.57%,屋尘螨分别为54.83%和47.89%,2组比较均差异有统计学意义（均P〈0.01）。结论：在同一地区拟诊为变应性鼻炎的患者中,使用不同变应原点刺试剂进行SPT,其总体阳性率有所不同,变应原种类较多者更易于提高检出阳性率;尘螨均为主要变应原,但不同试剂检出的阳性率不同,在决策特异性免疫治疗时应注意。

Skin prick test using two different allergen prick reagents,a comparative study in Shanghai

Objective：To compare the results of skin prick test with allergens of Allergopharma company or ALK company in Shanghai area. Method：The study included 9 233 patients diagnosed as allergic rhinitis. The pa- tients were divided in to two groups （Allergopharma group and Alutard-SQ group） SPT was given from June, 2005 to Feb, 2013. The results of the positive rate using two reagents were analyzed and compared. Result：There were no significant differences between the two groups in age and gender（P〉0.05）. The total positive rate in A1- lergopharma group was 62.90%, and 59.68% in Alutard-SQ group. The positive rate in Allergopharma group was significantly higher than that in Alutard-SQ group（P〈0.01）. Dermatophagoides farinae（Der f） and Dermato- phagoides pteronyssinus （Der p） were identified as the mostly responsible allergens. The positive rate of Der f in Allergopharma group and Alutard-SQ group was 55.23% and 45.57% respectively. The same rate were 54.83% and 47.89 % of Der p. There were significant differences of the positive rate of two allergens in both groups（P〈 0.01）. Conclusion：The total positive rate was different using different allergens for SPT among the patients diag- nosed as allergic rhinitis of the same area. Dust mites were identified as main allergens. The positive rate was dif- ferent when using different reagents, which needed more attention to make the decision of specific immune thera- py.