CD45RO在喉鳞状细胞癌中的表达及临床意义

目的：探讨喉鳞状细胞癌中cD45RO的表达及其临床意义，为喉鳞状细胞癌的预后评估提供新的思路，及为其生物治疗提供理论依据。方法：2010—01—2012—12期间我院确诊并手术治疗的初发喉鳞状细胞癌标本50例。另取10例喉部正常黏膜作对照分析。所有标本均经10％甲醛固定，石蜡包埋、切片。采用免疫组织化学、苏木精伊红染色方法检测CD45RO的阳性表达，分析其与喉鳞状细胞癌临床病理特征之间的关系。结果：CD45RO在正常组织及喉鳞状细胞癌中的阳性表达率分别为30％、86％。在50例喉癌病例中，CD45RO与局部淋巴结转移呈负相关（r=-0．713，P〈0．05），与肿瘤分区呈负相关（r=-0．750，P〈0．05），与年龄、T分类、病理分化程度、临床分期无明显相关性。结论：①CD45RO在喉鳞状细胞癌组织中的表达高于正常喉黏膜组织中的表达；②CD45RO过表达可能减少区域淋巴结转移；③CD45RO过表达可能有利于喉鳞状细胞癌患者的预后；④传统UICC—TNM分期、组织学分级评估预后不同，通过对CD45RO的检测可以从另外一个角度评估喉鳞状细胞癌的预后情况。

Expression and clinical significance of CD45RO in laryngeal carcinoma tissue

Objective：To investigate the role and significance of CD45RO in occurance and development in laryngeal squamous carcinoma,and to provide some valuable clues for searching new approaches to assess prognosis and theoretical basis for tumor biotherapy. Method： The expression of CD45RO protein in 50 cases of laryngeal squamous carcinoma and 10 cases normal mueos was detected by immunohistochemical S-P method. Result： The positive rate of CD45RO was 30% and 86% respectively in normal tissue and laryngeal squamous cell carcinoma tissue. The expresion of CD45RO was significantly and negatively associated with local metastatic of lymph nodes （r=-0. 713,P〈0.05） and tumor sites（r=-0. 750,P〈0.05） ,hut it have no notable difference with pathology differentiation,age,infiltrating depth and clinical stages in 50 cases of laryngeal squamous cell cancer. Conclusion： OThe expresion of CD45RO in laryngeal squamous cell cancer is more than that in normal tissue. （2） It is possible that overexpresion of CD45RO in laryngeal squamous cell carcinoma cut local metastatic lymph nodes. （3）It is probable that overexpresion of CD45RO in laryngeal squamous cell cancer made for prognosis of patients. （4）Other than UICC-TNM stage, pathology differentiation,it provide valuable clues for searching new approaches to assess prognosis of laryngeal squamous cell carcinoma.