Prevention of peritoneal adhesions: a promising role for gene therapy |
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| Authors: | Atta Hussein M |
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| Affiliation: | Hussein M Atta,Department of Surgery,Faculty of Medicine,Minia University,El-Minia 61519,Egypt |
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| Abstract: | Adhesions are the most frequent complication of abdominopelvic surgery,yet the extent of the problem,and its serious consequences,has not been adequately recognized.Adhesions evolved as a life-saving mecha-nism to limit the spread of intraperitoneal inflammatory conditions.Three different pathophysiological mechanisms can independently trigger adhesion formation.Mesothelial cell injury and loss during operations,tissue hypoxia and inflammation each promotes adhesion formation separately,and potentiate the e... |
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| Keywords: | Peritoneal adhesions Tissue plasminogen activator Gene therapy Plasminogen activator inhibi-tor Tissue inhibitor of metalloproteinase Transforminggrowth factor β |
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