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Topical application of glycyrrhizin preparation ameliorates experimentally induced colitis in rats |
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| Authors: | Kudo Tomohiro Okamura Shinichi Zhang Yajing Masuo Takashige Mori Masatomo |
| Affiliation: | Tomohiro Kudo,Yajing Zhang,Takashige Masuo,Masatomo Mori,Department of Medicine and Molecular Science,Gunma University Graduate School of Medicine,Gunma 371-8511,Japan Shinichi Okamura,Department of Medical Informatics and Decision Sciences,Gunma University School of Medicine,Japan |
| Abstract: | AIM:To examine the efficacy of glycyrrhizin preparation(GL-p) in the treatment of a rat model of ulcerative colitis(UC).METHODS:Experimental colitis was induced by oral administration of dextran sodium sulfate.Rats with colitis were intrarectally administered GL-p or saline.The extent of colitis was evaluated based on body weight gain,colon wet weight,and macroscopic damage score.The expression levels of pro-inflammatory cytokines and chemokines in the inflamed mucosa were measured by cytokine antibody arra... |
| Keywords: | Glycyrrhizin Colitis Dextran sodium sulfate Ulcerative colitis Cytokine Chemokine Protein array Myeloperoxidase Enema Carboxymethylcellulose |
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