Fascin promotes the motility and invasiveness of pancreatic cancer cells |
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| Authors: | Xu Yan-Feng Yu Shuang-Ni Lu Zhao-Hui Liu Jian-Ping Chen Jie |
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| Institution: | Yan-Feng Xu,Shuang-Ni Yu,Zhao-Hui Lu,Jian-Ping Liu,Jie Chen,Department of Pathology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Tsinghua University,Beijing 100730,China |
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| Abstract: | AIM:To explore the role of actin-bundling protein, fascin during the progression of pancreatic cancer. METHODS:The plasmid expressing human fascin-1 was stably transfected into the pancreatic cancer cell line MIA PaCa-2. The proliferation, cell cycle, motility, scattering, invasiveness and organization of the actin filament system in fascin-transfected MIA PaCa-2 cells and control non-transfected cells were determined. RESULTS:Heterogeneous overexpression of fascin markedly enhanced the motility, scattering... |
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| Keywords: | Fascin Invasiveness Motility Pancreatic cancer |
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