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Role of genetics in the diagnosis and prognosis of Crohn's disease |
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| Authors: | Tsianos Epameinondas V Katsanos Konstantinos H Tsianos Vasileios E |
| Institution: | Epameinondas V Tsianos,Konstantinos H Katsanos,Vasileios E Tsianos,1st Division of Internal Medicine and Hepato-Gastroenterology Unit,Department of Medicine,Medical School,University of Ioannina,Leoforos Stavrou Niarxou,PO Box 1186,45110 Ioannina,Greece |
| Abstract: | Considering the epidemiological, genetic and immunological data, we can conclude that the inflammatory bowel diseases are heterogeneous disorders of multifactorial etiology in which hereditability and environment interact to produce the disease. It is probable that patients have a genetic predisposition for the development of the disease coupled with disturbances in immunoregulation. Several genes have so far been related to the diagnosis of Crohn's disease. These genes are related to innate pattern recogni... |
| Keywords: | Crohn’s disease Genetics Polymorphism Diagnosis Prognosis Genome-wide scan Genetic consortium |
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