| Effects of α-mangostin on apoptosis induction of human colon cancer |
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| 作者姓名： | Ramida Watanapokasin Faongchat Jarinthanan Yukio Nakamura Nitisak Sawasjirakij Amornmart Jaratrungtawee Sunit Suksamrarn |
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| 作者单位： | Department of Biochemistry;Faculty of Medicine;Srinakharinwirot University;Faculty of Medical Technology;Rangsit University;Clinical Research Center;Murayama Medical Center;Department of Research;North Bangkok University;Department of Chemistry;Faculty of Science; |
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| 基金项目： | Supported by The Thailand Research Fund,Grant No. RMU 4980043 |
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| 摘 要： | AIM:To investigate the effect of α-mangostin on the growth and apoptosis induction of human colon cancer cells.METHODS:The three colorectal adenocarcinoma cell lines tested (COLO 205,MIP-101 and SW 620) were treated with α-mangostin to determine the effect on cell proliferation by MTT assay,cell morphology,chromatin condensation,cell cycle analysis,DNA fragmentation,phosphatidylserine exposure and changing of mitochondrial membrane potential.The molecular mechanisms of α-mangostin mediated apoptosis were fu...
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| 关 键 词： | α-mangostin Apoptosis Caspases Colon cancer Mitochondria |
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