Hepatitis B virus infection and the risk of hepatocellular carcinoma |
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| Authors: | Tan Ya-Jun |
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| Institution: | Ya-Jun Tan,Department of Laboratory Medicine,The First Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 310003,Zhejiang Province,China |
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| Abstract: | Epidemiological studies have provided overwhelming evidence for a causal role of chronic hepatitis B virus(HBV) infection in the development of hepatocellular carcinoma(HCC).However,the pathogenesis of HBV infection and carcinogenesis of HBV-associated HCC are still elusive.This review will summarize the current knowledge on the mechanisms involved in HBV-related liver carcinogenesis.The role of HBV in tumor formation appears to be complex,and may involve both direct and indirect mechanisms.Integration of H... |
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| Keywords: | Hepatocellular carcinoma Hepatitis B virus infection Hepatitis B virus genotypic variations Hepatitis B virus x protein |
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