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Chemometrics of differentially expressed proteins from colorectal cancer patients |
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| Authors: | Yeoh Lay-Chin Dharmaraj Saravanan Gooi Boon-Hui Singh Manjit Gam Lay-Harn |
| Affiliation: | Lay-Chin Yeoh,Lay-Harn Gam,School of Pharmaceutical Sciences,Universiti Sains Malaysia,Penang,11800,Malaysia Saravanan Dharmaraj,Centre for Drug Research,Malaysia Boon-Hui Gooi,Manjit Singh,Department of Surgery,Penang General Hospital,10990,Malaysia |
| Abstract: | AIM:To evaluate the usefulness of differentially expressed proteins from colorectal cancer (CRC) tissues for differentiating cancer and normal tissues.METHODS:A Proteomic approach was used to identify the differentially expressed proteins between CRC and normal tissues.The proteins were extracted using Tris buffer and thiourea lysis buffer (TLB) for extraction of aqueous soluble and membrane-associated proteins,respectively.Chemometrics,namely principal component analysis (PCA) and linear discriminant analy... |
| Keywords: | Colorectal cancer Proteomics Marker protein Principal component analysis Linear discriminant analysis |
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