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CXCR4/SDF-1 axis is involved in lymph node metastasis of gastric carcinoma |
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| Authors: | Zhao Bao-Cheng Wang Zhen-Jun Mao Wei-Zheng Ma Hua-Chong Han Jia-Gang Zhao Bo Xu Hui-Min |
| Affiliation: | Bao-Cheng Zhao,Zhen-Jun Wang,Hua-Chong Ma,Jia-Gang Han,Bo Zhao,Department of General Surgery,Beijing Chaoyang Hospital,Capital Medical University,Beijing 100020,China Wei-Zheng Mao,Qingdao Municipal Hospital,Qingdao University Medical College,Qingdao 266071,Shandong Province,China Hui-Min Xu,Weifang People's Hospital,Weifang 261041,Shangdong Province,China |
| Abstract: | AIM:To investigate the role of CXC chemokine receptor-4 (CXCR4) and stromal cell-derived factor-1 (SDF-1) in lymph node metastasis of gastric carcinoma.METHODS:In 40 cases of gastric cancer,expression of CXCR4 mRNA in cancer and normal mucous membrane and SDF-1 mRNA in lymph nodes around the stomach was detected using quantitative polymerase chain reaction (PCR) (TaqMan) and immunohistochemistric assay.SGC-7901 and MGC80-3 cancer cells were used to investigate the effect of SDF-1 on cell proliferation and m... |
| Keywords: | Gastric carcinoma Chemokines Stromal cell-derived factor-1 CXC chemokine receptor-4 Lymph node metastasis |
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