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Virological response to adefovir monotherapy and the risk of adefovir resistance |
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| Authors: | Sinn Dong Hyun Lee Hyang Ie Gwak Geum-Youn Choi Moon Seok Koh Kwang Cheol Paik Seung Woon Yoo Byung Chul Lee Joon Hyeok |
| Affiliation: | Dong Hyun Sinn,Geum-Youn Gwak,Moon Seok Choi,Kwang Cheol Koh,Seung Woon Paik,Byung Chul Yoo,Joon Hyeok Lee,Department of Medicine,Samsung Medical Center,Sungkyunkwan University School of Medicine,135-710 Seoul,South Korea Hyang Ie Lee,Department of Internal Medicine,Eulji University Hospital,302-799 Daejeon,South Korea |
| Abstract: | AIM:To evaluate virological response to adefovir(ADV) monotherapy and emergence of ADV-resistant mutations in lamivudine(LAM)-resistant chronic hepatitis B patients.METHODS:Seventy-seven patients with documented LAM resistance who were treated with 10 mg/d ADV for>96 wk were analyzed for ADV resistance.RESULTS:At week 48 and 96,eight(10%)and 14(18%)of 77 LAM-resistant patients developed the ADV-resistant strain(rtA181V/T and/or rtN236T mutations),respectively.Hepatitis B virus(HBV)DNA levels during therapy ... |
| Keywords: | Hepatitis B virus Viral DNA Adefovir Lamivudine Drug resistance |
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