rAd-p53 enhances the sensitivity of human gastric cancer cells to chemotherapy |
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| Authors: | Chen Guang-Xia Zheng Li-Hong Liu Shi-Yu He Xiao-Hua |
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| Affiliation: | Guang-Xia Chen,Shi-Yu Liu,Xiao-Hua He,Department of Gastroenterology,First People's Hospital of Xuzhou,Xuzhou 221002,Jiangsu Province,China Li-Hong Zheng,Yantai Economic and Technological Development Zone Hospital,Yantai 264006,Shandong Province,China |
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| Abstract: | AIM:To investigate potential antitumor effects of rAd-p53 by determining if it enhanced sensitivity of gastric cancer cells to chemotherapy.METHODS:Three gastric cancer cell lines with distinct levels of differentiation were treated with various doses of rAd-p53 alone,oxaliplatin(OXA) alone,or a combination of both.Cell growth was assessed with an 3-(4,5)-dimethylthiahiazo(-z-y1)-3,5-diphenytetrazoliumromide assay and the expression levels of p53,Bax and Bcl-2 were determined by immunohistochemistry.The pre... |
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| Keywords: | Gastric cancer rAd-p53 Oxaliplatin Chemosensitivity Apoptosis |
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