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Vascular endothelial growth factor 165b expression in stromal cells and colorectal cancer |
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| Authors: | Tayama Makoto Furuhata Tomohisa Inafuku Yoshiko Okita Kenji Nishidate Toshihiko Mizuguchi Toru Kimura Yasutoshi Hirata Koichi |
| Affiliation: | Makoto Tayama,Tomohisa Furuhata,Yoshiko Inafuku,Kenji Okita,Toshihiko Nishidate,Toru Mizuguchi,Yasutoshi Kimura,Koichi Hirata,the First Department of Surgery,Sapporo Medical University,South 1,West 16,Chuo-ku,Sapporo 060-8543,Japan |
| Abstract: | AIM:To characterize the implications of vascular endothelial growth factor(VEGF)-A in stromal cells and colorectal cancer and the expression of VEGF-A splice variants.METHODS:VEGF-A expression in tumor and stromal cells from 165 consecutive patients with colorectal cancer was examined by immunohistochemistry.The association between VEGF-A expression status and clinicopathological factors was investigated.Twenty freshfrozen samples were obtained for laser capture microdissection to analyze the splice variant... |
| Keywords: | Colorectal cancer Vascular endothelial growth factor-A Vascular endothelial growth factor 165 Microvascular density Stromal cell |
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