| Antioxidative potential of a combined therapy of anti TNFα and Zn acetate in experimental colitis |
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| 作者姓名： | Barollo M Medici V D'Incà R Banerjee A Ingravallo G Scarpa M Patak S Ruffolo C Cardin R Sturniolo GC |
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| 作者单位： | Department of Surgical and Gastroenterological Sciences;University of Padova;Padova 35128;Italy;Department of Internal Medicine;Division of Gastroenterology and Hepatology;University of California;Davis;CA 95616;United States;Department of Pathology;University of Bari;Bari 70121;Department of Oncological Surgery;Veneto Oncological Institute; |
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| 基金项目： | Supported by MIUR 40% University of Padova |
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| 摘 要： | AIM:To evaluate whether combination therapy with antitumour necrosis factor α (TNFα) antibody and Zn acetate is beneficial in dextran sodium sulphate (DSS) colitis.METHODS:Colitis was induced in CD1-Swiss mice with 5% DSS for 7 d.The experimental mice were then randomised into the following subgroups:standard diet + DSS treated (induced colitis group);standard diet + DSS + subcutaneous 25 μg anti-TNFα treated group;Zn acetate treated group + DSS + subcutaneous 25 μg anti-TNFα;standard diet + DSS + subcutane...
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| 关 键 词： | 肿瘤坏死因子 综合治疗 醋酸锌 结肠炎 抗氧化 实验性 DNA加合物 过氧化物酶活性 |
| 收稿时间： | 2010-12-15 |
| 本文献已被 CNKI 维普 PubMed 等数据库收录！ |
