温阳散寒补气养血法对非小细胞肺癌患者外周血树突状细胞影响的研究

目的观察温阳散寒补气养血法治疗非小细胞肺癌的临床疗效及其对外周血树突状细胞的影响。方法将41例非小细胞肺癌患者随机分为两组,对照组20例予常规方案化疗,治疗组21例在对照组治疗同时予温阳散寒补气养血法治疗,共治疗56d;比较两组患者原发灶改变及新转移灶发生情况、生存质量评分变化、外周血树突状细胞计数变化。结果两组原发灶瘤体变化相近;治疗组淋巴结转移率低于对照组,生存质量评分提高及稳定率高于对照组;治疗组治疗后树突状细胞计数及其与外周血单核细胞比值升高。结论温阳散寒补气养血法配合化疗治疗非小细胞肺癌能减少转移,提高生存质量,其疗效机制可能与提高树突状细胞数量有关。

linical Study of Warming Yang to Expel Coldness and Invigorating Qi and Nourishing Blood Recipe on the Dendritic Cell in Peripheral Blood of Non-small Cell Lung Cancer

Objective:To observe the clinical efficiency of patients with non-small cell lung cancer (NSCLC) and change of dendritic cell (DC) in peripheral blood.Methods:41 patients of NSCLC were divided into control group and treating group randomly.20 patients in control group were given routine chemotherapy.21 patients in treating group were given Warming Yang to Expel Coldness and Invigorating Qi and Nourishing Blood Recipe (WYECIQNBR) and routine chemotherapy in the same time.After 56 days,measured the dimension of primary tumor,the metastasis,the change of KPS,DC in peripheral blood.Results:There were no significant difference between these two groups in the dimension of primary tumor.The metastasis of lymph node of treating group was significantly less than control group.The improvement and stabilization ratio of KPS in treating group was significantly higher than control group.The DC in peripheral blood of treating group was significantly higher than control group after treatment.Conclusion:WYECIQNBR combined with chemotherapy can reduce the metastasis of lymph node and improve the living quality of NSCLC patients.The mechanism of efficiency has some relationship with the improvement of the number of DC.