| 氟烷七氟醚对酶诱导缺氧大鼠脂过氧化反应的影响（氟烷性肝炎的研究Ⅰ） |
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| 引用本文： | 俞卫锋,刘树孝,王景阳,于布为. 氟烷七氟醚对酶诱导缺氧大鼠脂过氧化反应的影响（氟烷性肝炎的研究Ⅰ）[J]. 临床麻醉学杂志, 1994, 0(1) |
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| 作者姓名： | 俞卫锋 刘树孝 王景阳 于布为 |
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| 作者单位： | 第二军医大学长海医院麻醉科 |
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| 摘 要： | 雄性ＳＤ大鼠饮用含苯巴比妥（１ｍｇ／ｍｌ）的饮水一周后，随机分为６组，每组６例：ＮＣ，２１％Ｏ２／７９％Ｎ２；ＨＣ，１４％０；１８６％Ｎｅ；ＮＨ，２１％Ｏ２／７９％Ｎ２／１．２ＭＡＣ氟烷；ＨＨ，１４％Ｏ２／８６％Ｎ２／１．２ＭＡＣ氟烷；ＮＳ，２１％Ｏ２／７９％Ｎ２／１．２ＭＡＣ七氟醚；ＨＳ，１４％Ｏ２／８６％Ｎ２／１．２ＭＡＣ七氟醚。吸入时间１ｈ，２４ｈ后测定血浆及肝匀浆中ＭＤＡ、ＳＯＤ、游离琉基的含量。结果ＨＨ、ＮＨ组肝匀浆及血浆中ＭＤＡ、ＳＯＤ的含量均高于其它各组（Ｐ＜０．０１，Ｐ＜０．０５），余各组间均无显著差异（Ｐ＞０．０５）。ＮＨ、ＨＨ组血浆及肝匀浆中游离琉基的含量显著低于其它各组（Ｐ＜０．０１）。提示氟烷所致的肝脂过氧化反应增强的作用可能与其肝毒性有关，而七氟醚无促进肝脏脂过氧化反应增强的作用。
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| 关 键 词： | 挥发性麻醉药；肝毒性；脂过氧化反应 |
The Effects of Halothane and Sevoflurane on Lipid Peroxidation in Enzyme-induced,Hypoxic Rats |
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| Yu Wei-feng,et al. The Effects of Halothane and Sevoflurane on Lipid Peroxidation in Enzyme-induced,Hypoxic Rats[J]. The Journal of Clinical Anesthesiology, 1994, 0(1) |
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| Authors: | Yu Wei-feng et al |
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| Abstract: | Male Sprague-Dawley rats were pretreated with phenobarbital and randomly divided into 6 groups and exposedto O2/N2/1. 2 MAC anesthetics for 1 hr:NC,21%O2/79%N2;HC,14%O286%N2;N3,21%O2/79%N2/1.2MACsevoflurane;HS,14%O2/86%N2/1.2 MAC sevoflurane;NH, 21%O2/70%N2/1.2MAC halothane;HH,14%O2/86%N2/1.2MAC halothane. The contents of MDA,SOD,SH in plasma and liver were measured 24 h after expo-sure concluded.The rats given halothane had significantly enhanced MDA,SOD values. The NH,HH groups hadsignificantly lower SH values than the other groups.It is concluded that lipoperoxidation of hepatic cell membranesby active free radicals produced during metabolism of halothane may be responsible for halothane-associated liver injury. |
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| Keywords: | Volatile anesthetics Hepatotoxicity Lipid peroxidation |
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