抗血小板治疗导致胃肠道损伤及其防治的研究进展

抗血小板药物治疗是进行心脑血管疾患预防及治疗的基石,广泛应用于临床.但长期使用可造成胃肠道损害,导致消化道出血等严重不良事件发生.如何在抗血小板治疗的同时进行消化系不良反应的防治,是目前临床面临的重要问题.本文就常用抗血小板药物阿司匹林和氯吡格雷导致胃肠道损害的作用机制、特点、防治措施等相关问题进行阐述,并对抗血小板药物相关消化道出血诊治指南和专家共识介绍.

Preventive and therapeutic strategies for gastrointestinal injury associated with antiplatelet therapy

Antiplatelet therapy is the basic therapy for cardiovascular diseases and is widely used in clinical practice.It can cause damage to the gastrointestinal tract and induce severe events such as gastrointestinal bleeding.It is very important for clinicians to prevent and treat this side effect in patients taking low-dose aspirin and clopidogrel.In this paper we discuss the mechanism,prevention and treament of gastrointestinal injury caused by aspirin and clopidogrel,and introduce the consensus recommendations on reducing the gastrointestinal risk of antiplatelet therapy.