妊娠合并乙型肝炎病毒感染对妊娠结局的影响

目的 探讨妊娠合并乙型肝炎病毒感染及无症状乙型肝炎病毒携带状态对妊娠结局的影响.方法 将173例在我院住院分娩的妊娠合并HBV感染者患者分为两组:无症状乙肝病毒携带者82例(无症状组)、肝功能受损者91例(乙肝组).随机选择同期90例正常产妇作为对照组,对围生期结局进行回顾性分析比较.结果 乙肝组早产、妊高征、胎儿窘迫、新生儿窒息、产后出血的发生率最高,依次是14.29％,27.47％,39.56％,24.18％,23.08％,无症状组相应为3.66％,12.20％,20.73％,8.54％,9.76％,对照组相应为1.11％,3.33％,17.78％,6.67％,4.44％,乙肝组与另两组比较差异有统计学意义(P＜0.01).结论 妊娠合并乙型肝炎病毒感染与早产、妊高征、胎儿窘迫、新生儿窒息、产后出血等不良妊娠结局有关,应重视产前检查及孕期肝功能检测,尽早采取预防及治疗措施.

Effect of hepatitis B virus infection during pregnancy on the pregnancy outcome.

Objective To investigate the effect of hepatitis B virus infection during pregnancy on the pregnancy outcome. Methods A retrospective study was conducted on the perinatal outcome of 173 cases of hepatitis B virus infection during pregnancy and 90 cases of normal pregnancy (the control group. The 173 patients were divided into two groups: group A (Hepatitis B virus carriers without symptoms) and group B (Hepatitis B virus carriers with impaired liver function). Results The incidence of premature delivery, pregnancy-induced hypertension syndrome, fetal distress, newborn asphyxia and postpartum hemorrhage in group B were 14.29%, 27.47%, 39.56%, 24.18%, 23.08%, respectively, significantly higher than the other two groups (P<0.01). Conclusion Hepatitis B infection during pregnancy can affect the pregnancy outcome significantly, thus prenatal examination and liver function test during pregnancy should be emphasized.