| 海洋放线菌—药物开发的新兴资源 |
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| 引用本文： | 蔡超靖,丁彦博,单越琦,穆云龙. 海洋放线菌—药物开发的新兴资源[J]. 国外医药(抗生素分册), 2012, 33(1): 22-29,42 |
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| 作者姓名： | 蔡超靖 丁彦博 单越琦 穆云龙 |
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| 作者单位： | 华北制药集团新药研究开发有限责任公司微生物药物国家工程研究中心河北省工业微生物代谢工程技术研究中心,石家庄,050015 |
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| 摘 要： | 近些年,海洋放线菌成为新药研发的重要来源,引起人们的关注,本文综述了海洋放线菌在分离方面取得的成绩,并介绍了通过传统筛选方法分离得到的生物活性代谢物,以及在与新化合物相关的基因挖掘和生物合成基因簇的异源表达方面取得的进展。
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| 关 键 词： | 海洋放线菌 活性代谢产物 基因组学 异源表达 |
Marine Actinomycetes- an Emerging Resource for the Drug Discovery |
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| Cai Chao-Jing,Ding Yan-Bo,Shan Yue-Qi,Mu Yun-Long. Marine Actinomycetes- an Emerging Resource for the Drug Discovery[J]. world notes on antibiotics, 2012, 33(1): 22-29,42 |
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| Authors: | Cai Chao-Jing Ding Yan-Bo Shan Yue-Qi Mu Yun-Long |
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| Affiliation: | (New Drug Research ＆ Development Center of North China Pharmaceutical Group Corporation, National Microbial Medicine Engineering ＆ Research Center, Hebei Industrial Microbial Metabolic Engineering Research Center, Shijiazhuang 050015 ) |
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| Abstract: | As an important resource of the new drugs, more and more attentions were paid on marine actinomycetes recently. This review highlights achievements in the isolation of marine actinomycetes, some examples of bioactive metabolites identified by traditional screening, and presents new progress in the field of genome mining leading to the discovery of novel compounds and heterologous expression of biosynthetic gene clusters. |
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| Keywords: | marine actinomycetes bioactive secondary metabolites genomics heterologous expression |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ |
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