Chronic evaluation of the Cleveland Clinic CorAide left ventricular assist system in calves |
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Authors: | Fukamachi Kiyotaka Ochiai Yoshie Doi Kazuyoshi Massiello Alex L Medvedev Alexander L Horvath David J Gerhart Renee L Chen Ji-Feng Krogulecki Alexandra Y Takagaki Masami Howard Michael W Kopcak Michael W Golding Leonard A R |
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Affiliation: | Department of Biomedical Engineering and Biological Resources Unit, Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, Ohio, U.S.A. |
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Abstract: | The Cleveland Clinic CorAide left ventricular assist system is based on a third-generation, implantable, centrifugal pump in which a rotating assembly is suspended fully. To evaluate chronic in vivo system performance and biocompatibility, the CorAide blood pump was implanted in 18 calves for either 1 month or 3 months. Hemodynamics were stable in all calves with a mean pump flow of 5.9 +/- 1.2 L/min and a mean systemic arterial pressure of 98 +/- 5 mm Hg. There were no incidences of bleeding, organ dysfunction, or mechanical failure in any of the 18 calves. Hemolysis occurred in only 1 calf due to outflow graft stenosis. Thrombus inside the pump, seen in 4 of the first 6 cases, was totally eliminated by a final redesign in the remaining cases, including the last 6 implants conducted without anticoagulation therapy. The CorAide blood pump demonstrated good biocompatibility and reliable, effective system performance. |
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Keywords: | Centrifugal pump Left ventricular assist device Anticoagulation Hemolysis |
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