| 食管癌细胞DNA含量和细胞周期的分析 |
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| 引用本文： | 张冬成,陈秉燮,卢诗杰,梅品超. 食管癌细胞DNA含量和细胞周期的分析[J]. 汕头大学医学院学报, 1998, 11(4): 7-9 |
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| 作者姓名： | 张冬成 陈秉燮 卢诗杰 梅品超 |
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| 作者单位： | 汕头大学医学院附属肿瘤医院胸外科!湖南医科大学(张冬成)，汕头大学医学院附属肿瘤医院胸外科(陈秉燮，卢诗杰)，汕头大学医学院中心实验室(梅品超) |
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| 摘 要： | 报道100例食管瘤手术切除新鲜标本组织的DNA含量和细胞周期的流式细胞光度分析。结果显示癌细胞DNA非整倍体（AN）检出率为70．7％，细胞增殖指数（PI）为（20．79．1）％（xS）；非整倍体肿瘤S期细胞比例和PI显著高于二倍体肿瘤（P＜0．05和P＜0．01）。食管癌AN与肿瘤细胞分化和局部淋巴结转移密切相关（P＜0．05和P＜0.01）。食管癌流式细胞的DNA含量和细胞周期的分析在揭示肿瘤恶性生物学行为、指导临床治疗方面具有重要的意义。
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| 关 键 词： | 食管癌 流动血细胞计数 DNA含量 细胞周期 |
Flow Cytometric Nuclear DNA Content and Cellular Cycle Analysis of Esophageal Carcinoma |
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| Zhang Dongcheng, Chen Binxie, Lu Shijic, Mei Pingchao. Flow Cytometric Nuclear DNA Content and Cellular Cycle Analysis of Esophageal Carcinoma[J]. Journal of Shantou University Medical College, 1998, 11(4): 7-9 |
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| Authors: | Zhang Dongcheng Chen Binxie Lu Shijic Mei Pingchao |
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| Abstract: | Flow cytometric nuclear DNA content and cellular Cycle analyses were Performed onesophageal careinoma from 100 patients. The result indicates that DNA aneuploidy (AN) was idenhfiedin 70.7% of patient, the proliferation index (PI) was (22.7 1 9. 1 ) (x s). S -- Phase fraction andPI of aneuploid tomor were significantly higher lean those of diploid tumor (P < 0.05). AN was foundto closely correlate with hath tumor cell differenhation and the frequency of lymph "the metaStaSes (P <0.05 and P < 0.01 ). Thus, flow cytometric DNA content and cellular Cycle analysis Of esopllageal carcinoma are valued method indetermining the highly malignant potential and detecting clinical therapy. |
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| Keywords: | Esophageal Carcinoma Flow Cytometry DNA Content Cell Cycle |
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