纤溶酶原激活物抑制剂-1与急性心肌梗死关系的研究

目的探讨纤溶酶原激活物抑制剂-1(PAI-1)在急性心肌梗死(AMI)发病中的作用。方法应用发色底物法测定中国汉族AMI患者56例(男44,女12,平均年龄67±10岁)和正常对照组55例(男42,女13,年龄68±8岁)血浆PAI-1活性,并分析环境因素对PAI-1水平的影响。结果 (1)AMI组和正常对照组的血浆PAI-1水平分别为O.90±O.13Au/ml和O.72±O.13Au/ml,两组间比较有显著性差异(P<0.001)。(2)吸烟、高血压病史、既往血栓性疾病病史、冠心病家族史、体重指数(BMI)、三酰甘油(TG)、血糖水平均与血浆PAI-1水平呈正相关,多元逐步回归分析显示,高血压病史、冠心病家族史是血浆PAI-1水平的独立预测因素。结论血浆PAI-1水平增加是心肌梗死(MI)的危险因素;(2)高血压、冠心病家族史为PAI-1水平的独立决定因素。

Study on the relationship between plasminogen activator inhibitor-1 (PAI-1) levels and acute myocardial infarction

Objective To reveal the relationship between PAI-1 levels and myocardial infarction (MI)in Chinese Han ethnic group and to provide an objective evidence in the prophylaxes and management of AMI. Methods The subjects of the study consist of two groups; (1) AMI group (44 men and 12 women; mean age 67 10); (2) normal-control group (42 men and 13 womeni mean age 68i8). The PAI-1 activity was measured by chromophorous substrate method. The relationship between some cardiovascular risk factors and the PAI-1 levels was investigated. Results (1) The PAI-1 activity levels in AMI and normal control group was 0. 90 0. 13Au/ml, 0. 72 0. 13Au/ ml. respectively (P<0. 001). (2) In all of the samples, the levels of PAI-1 activity were influenced by smoking, history of hypertension and thrombosis, family history of coronary heart disease(CHD), body mass index(BMI), serum triglyceride and glucose levels. Multiple regression analyses disclosed that the plasma PAI-1 levels were determined by history of hypertension and family history of CHD. Conclusions The present data suggest that (1) increased levels of circulating PAI-1 is a risk factor of MI; (2) the PAI-1 levels were independently determined by history of hypertension and family history of CHD.