| 血清基质金属蛋白酶与不同类型心绞痛病人近期预后的关系 |
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| 引用本文： | 魏芳晶,阴淑莹,张晓云,王翠艳,徐敏.血清基质金属蛋白酶与不同类型心绞痛病人近期预后的关系[J].内蒙古医学院学报,2009,31(4):353-356. |
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| 作者姓名： | 魏芳晶 阴淑莹 张晓云 王翠艳 徐敏 |
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| 作者单位： | 内蒙古医学院附属医院,保健中心,内蒙古,呼和浩特,010050 |
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| 基金项目： | 内蒙古自治区自然科学基金 |
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| 摘 要： | 目的：探讨未接受介入治疗的不同类型心绞痛病人血清基质金属蛋白酶-9（MMP-9）、基质金属蛋白酶组织抑制因子-1（TIMP-1）水平的变化与近期预后的关系。方法：46例不稳定型心绞痛病人为UAP组,36例稳定型心绞痛病人为SAP组,30名体检健康者为对照组。比较各组血清MMP-9和TIMP-1水平变化;随访3mo主要心血管事件。结果：UAP组入院第1d MMP-9水平高于SAP组（P〉0.05）,前者持续在第3d（272.23±20.09 vs 165.57±22.34）ng/mL、第7d继续升高（337.35±53.12 vs 125.22±27.25）ng/mL,后者则持续下降（P〈0.05）;TIMP-1表现同样的变化趋势。3mo随访期间发生心脏事件33例,无心脏事件49例。有心脏事件入院第1、3、7d血清MMP-9水平高于无心脏事件（P〈0.05）。结论：UAP病人MMP-9、TIMP-1血清水平动态升高,与近期心血管事件有关。MMP-9、TIMP-1可作为不同类型心绞痛病人危险分层的指标之一。
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| 关 键 词： | 心绞痛 基质金属蛋白酶-9 基质金属蛋白酶组织抑制因子-1 |
THE SHORT-TERM PROGNOSTIC VALUE OF MMP-9 IN PATIENTS WITH UNSTABLE AND STABLE ANGINA PECTORIS |
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| WEI Fang-jing,YIN Shu-ying,ZHANG Xiao-yun,et al..THE SHORT-TERM PROGNOSTIC VALUE OF MMP-9 IN PATIENTS WITH UNSTABLE AND STABLE ANGINA PECTORIS[J].Acta Academiae Medicinae Neimongol,2009,31(4):353-356. |
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| Authors: | WEI Fang-jing YIN Shu-ying ZHANG Xiao-yun |
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| Institution: | WEI Fang-jing,YIN Shu-ying,ZHANG Xiao-yun,et al.(Department of Cardiology,Affiliated Hospital,Inner Mongolia Medical College,Hohhot 010050 China) |
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| Abstract: | Objective:To study the serum level of matrix metalloproteinase-9(MMP-9),tissue inhibitors of matrix metalloproteinase-1(TIMP-1)and its short-term prognosticvalue for patients with angina pectoris(AP).Methods:46 cases of patients with unstable angina pectoris(UAP) and 36 cases of patients with stable angina pectoris(SAP).While 30 cases of healthy individuals were selected as control group.The serum levels of MMP-9 and TIMP-1 were compared.Results:Serum levels of MMP-9 were significantly higher at 3rd day(272... |
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| Keywords: | angina pectoris matrix metalloproteinase-9(MMP-9) tissue inhibitor of matrix metalloproteinase-1(TIMP-1) |
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