Metabolic factors and the risk of colorectal cancer in 580,000 men and women in the metabolic syndrome and cancer project (Me‐Can) |
| |
| Authors: | Tanja Stocks PhD Annekatrin Lukanova MD PhD Tone Bjørge MD PhD Hanno Ulmer MD PhD Jonas Manjer MD PhD Martin Almquist MD PhD Hans Concin MD Anders Engeland PhD Göran Hallmans MD PhD Gabriele Nagel MD PhD Steinar Tretli PhD Marit B. Veierød PhD Håkan Jonsson PhD Pär Stattin MD PhD |
| |
| Affiliation: | 1. Department of Surgical and Perioperative Sciences, Urology and Andrology, Ume? University, Ume?, Sweden;2. Institute of Health Sciences, Free University, Amsterdam, The NetherlandsFax: (011) 46 90 1253 96;3. Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany;4. Department of Public Health and Primary Health Care, University of Bergen, Bergen, Norway;5. Norwegian Institute of Public Health, Bergen, Norway;6. Department of Medical Sciences, Informatics and Health Economics, Innsbruck Medical University, Innsbruck, Austria;7. Department of Surgery, Malm? University Hospital, Malm?, Sweden;8. Department of Surgery, Lund University Hospital, Lund, Sweden;9. Agency for Preventive and Social Medicine, Bregenz, Austria;10. Department of Public Health and Clinical Medicine, Nutritional Research, Ume? University, Ume?, Sweden;11. Institute of Epidemiology, Ulm University, Ulm, Germany;12. Institute of Population‐based Cancer Research, Cancer Registry of Norway, Oslo, Norway;13. Department of Biostatistics, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway;14. Department of Radiation Sciences, Oncology, Ume? University, Ume?, Sweden |
| |
| Abstract: | BACKGROUND: The metabolic syndrome (MetS) has been related to an increased risk of colorectal cancer, but the modest size of previous studies precluded detailed characterization of the role of individual MetS factors and their interaction on risk. METHODS: In the Metabolic Syndrome and Cancer Project (Me‐Can), data on body mass index (BMI), blood pressure, and blood levels of glucose, cholesterol, and triglycerides were available for 578,700 men and women. The mean age of participants at baseline was 44 years, and the mean follow‐up was 12 years. Relative risks (RR) of colorectal cancer per 1 standard deviation increment in Z score of factors and for a combined MetS score, were calculated from Cox regression models, including adjustment for potential confounders. RESULTS: During follow‐up, 2834 men and 1861 women were diagnosed with colorectal cancer. The RR of colorectal cancer for the MetS score was 1.25 (95% confidence interval [CI], 1.18‐1.32) in men, and 1.14 (95% CI, 1.06‐1.22) in women. Significant associations also were observed in men for BMI (RR, 1.07; 95% CI, 1.02‐1.13), blood pressure (RR, 1.10; 95% CI, 1.02‐1.18), and triglycerides (RR, 1.17; 95% CI, 1.06‐1.28) and, in women, for BMI (RR, 1.08; 95% CI, 1.01‐1.15). There was no significant positive interaction between the metabolic factors on risk. CONCLUSIONS: The combination of metabolic factors and some separate factors was related to an increased risk of colorectal cancer, but there was no interaction between metabolic factors. Cancer 2011;. © 2010 American Cancer Society. |
| |
| Keywords: | epidemiology cohort studies colorectal neoplasms overweight blood pressure blood glucose cholesterol triglycerides metabolic syndrome X |
|
|
