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Genetic Factors That Affect Spontaneous Clearance of Hepatitis C or B Virus,Response to Treatment,and Disease Progression |
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| Authors: | Thomas R. O&#x Brien,Hwai-I Yang,Sarah Groover,Wen-Juei Jeng |
| Affiliation: | 1. Infections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland;2. Genomics Research Center, Academia Sinica, Taipei, Taiwan;3. Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan;4. Department of Biochemistry and Microbiology, Oklahoma State University Center for Health Sciences, Tulsa, Oklahoma;5. Department of Gastroenterology and Hepatology, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan;6. College of Medicine, Chang Gung University, Taoyuan, Taiwan;7. Liver Research Unit, Chang Gung Memorial Hospital, Linkou, Taoyuan, Taiwan |
| Abstract: | |
| Keywords: | Epidemiology Fibrosis Hepatocellular Carcinoma ALT alanine aminotransferase cccDNA covalently closed circular DNA CHB chronic HBV infection CHC chronic HCV infection DAA direct-acting antiviral GWAS genome-wide association study HBeAg hepatitis B e antigen HBsAg hepatitis B surface antigen HBV hepatitis B virus HCC hepatocellular carcinoma HCV hepatitis C virus IL interleukin ITP inosine triphosphate KIR killer-cell immunoglobulin-like receptor LD linkage disequilibrium MHC major histocompatibility complex NAFLD nonalcoholic fatty liver disease NF nuclear factor NTCP sodium taurocholate co-transporting polypeptide Nuc nucleos(t)ide analogue SNP single-nucleotide polymorphism SVR sustained viral response UTR untranslated region |
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