Design and synthesis of novel NO‐donor‐ferulic acid hybrids as potential antiatherosclerotic drug candidatesa |
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| Authors: | Nian‐Guang Li Rong Wang Zhi‐Hao Shi Yu‐Ping Tang Bao‐Quan Li Zhen‐Jiang Wang Shu‐Lin Song Li‐Hua Qian Li Wei Jian‐Ping Yang Li‐Juan Yao Jun‐Zuan Xi Jia Xu Feng Feng Da‐Wei Qian Jin‐Ao Duan |
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| Institution: | 1. Jiangsu Key Laboratory for TCM Formulae Research, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, People's Republic of China;2. Department of Medicinal Chemistry, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210046, People's Republic of China;3. Department of Organic Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 211198, People's Republic of China;4. Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing, Jiangsu 210009, People's Republic of China |
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| Abstract: | Novel NO‐donor‐ferulic acid hybrids were designed and synthesized through a symbiotic approach using ferulic acid and three different NO‐donating groups, such as nitric ester, 4‐hydroxyl‐3‐phenylfuroxan, and 4‐hydroxymethyl‐3‐phenylsulfonylfuroxan. Antioxidant, nitric oxide release, and vasodilator properties studies showed that the target phenylsulfonylfuroxan 14, especially 14c, while keeping the antioxidant activity, showed more NO release activity and vasodilating activity than isosorbide dinitrate (ISDN). Thus, 14c may be considered a novel potent anti‐atherosclerosis drug candidate. Drug Dev Res 72: 405–415, 2011. © 2011 Wiley‐Liss, Inc. |
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| Keywords: | atherosclerosis nitric oxide donor ferulic acid nitric oxide release |
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