递质性氨基酸在缺血性脑血管病患者血浆中的变化及临床意义

目的探讨递质性氨基酸变化在老年人缺血性脑血管病患者中的临床意义。方法应用高效液相色谱法（HPLC）测定66例老年人缺血性脑血管病患者和35名正常老年人血浆中兴奋性和抑制性氨基酸。结果在脑缺血急性期，血浆兴奋性氨基酸谷氨酸（Glu）、天冬氨酸（Asp）水平分别为：（91．71±15．77）和（22．32±9．45）μmol／L，与正常对照组相比明显升高（P〈0．01），两者在恢复期降至正常水平。血浆抑制性氨基酸γ-氨基丁酸（GABA）、甘氨酸（Gly）、丙氨酸（Ala）在脑缺血急性期也显著升高（P〈0．05），分别为：（3．15±1．21）、（96．33±20．21）和（301．44±58．33）μmol／L，GABA在恢复期有所下降，而Gly、Ala未见明显下降。结论：缺血性脑血管病患者血浆递质性氨基酸的水平可反映脑组织氨基酸递质的变化，与老年人缺血性脑血管病发生、发展、预后相关。

Clinical importance of transmitter amino acids determination in plasma of the patients with ischemic cerebrovascular diseases

Objective] To investigate the level of transmitter amino acids in plasma of the patients with ischemic cerebrovascular diseases and its clinical implication. Methods] Excitatory and inhibitory amino acids in plasmas of 66 senile patients with ischemic vascular disorders and 35 normal old people were detected by high performance liquid chromatography (HPLC). Results] The plasma levels of excitatory amino acids were significantly increased in acute stage of cerebral ischemia (P <0.01) and returned to the n...