| 对氨基水杨酸异烟肼对耐INH及PAS结核菌株的耐药实验观察 |
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| 引用本文： | 孙丽,席家宁,康丽君,晏华琪. 对氨基水杨酸异烟肼对耐INH及PAS结核菌株的耐药实验观察[J]. 中国防痨杂志, 2001, 23(2): 110-111 |
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| 作者姓名： | 孙丽 席家宁 康丽君 晏华琪 |
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| 作者单位： | 北京胸科医院 100095； |
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| 摘 要： | 目的 了解对氨基水杨酸异烟肼 (PSNZ)对耐异烟肼 (INH)及对氨基水杨酸钠 (PAS)的结核菌株耐药情况。方法 用改良罗氏培养基观察36株同时耐INH和PAS及149株对INH和PAS敏感的结核菌株对PSNZ药敏结果。结果 36株耐INH和PAS的结核菌株在1μg/ml浓度下有44.4%的菌株对PSNZ有效，149株对INH和PAS均敏感的结核菌株在1μg/ml浓度下有96%的结核菌株对PSNZ敏感。结论 PSNZ对耐INH和/或PAS的结核菌株仍显示一定程度的敏感，是一种独立的抗结核药物，可作为治疗耐多药结核病的有效药物之一。
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| 关 键 词： | 对氨基水杨酸异烟肼 分枝杆菌 结核 耐药 |
| 修稿时间： | 2000-03-06 |
Drug resistance observation on pasiniazide for the TB bacteria resistant to INH and PAS |
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| SUN Li,XI Jia ning,KANG Li jun,et al.. Drug resistance observation on pasiniazide for the TB bacteria resistant to INH and PAS[J]. The Journal of The Chinese Antituberculosis Association, 2001, 23(2): 110-111 |
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| Authors: | SUN Li XI Jia ning KANG Li jun et al. |
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| Affiliation: | Beijing Chest Hospital 100095 |
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| Abstract: | Objective To determine the PSNZ drug resistance incidence among INH and PAS-resistant M.tuberculosis.Methods By applying the reformed L-J medium, observe and compare the drug-resistance and drug-susceptibility to PSNZ in 36 INH and PAS resistant-M. tuberculosis, and 149 INH and PAS sensitive M. tuberculosis.Results 44.4% of the 36 INH and PAS resistant-M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml; 96% of the 149 INH and PAS sensitive M. tuberculosis are susceptible to PSNZ at the concentration of 1μg/ml.Conclusion PSNZ is still effective to some of the TB bacteria resistant to INH and/or PAS. It is an independent anti-TB drug. It can be used as one of the effective drugs for treat the MDR-TB. |
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| Keywords: | Pasiniazide Mycobacterium tuberculosis Drug resistance |
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