Technology for Preparation of Pure Total Flavonoid Fraction from Roots of <Emphasis Type="Italic">Pseudophora alopecuroides</Emphasis> and Evaluation of Its Hepatoprotector and Biligenic Activity

The optimal regime for extraction of the total flavonoid fraction from the roots of Pseudosophora alopecuroides has been found and the corresponding technological scheme for the isolation of flavonoids from this medicinal plant has been developed. Acomparative pharmacological investigation showed that both the total flavonoid extract obtained using a semicommercial apparatus according to the proposed technology and a laboratory preparation are comparable in activity with the well-known drug tanacechol based on common tansy flowers. This result shows that Pseudosophora alopecuroides offers an important source of biologically active flavonoids possessing hepatoprotector and biligenic activity. The annular natural resource of roots of this medicinal plant has been evaluated. The qualitative composition of the flavonoids and their total content in various extracts have been compared.__________Translated from Khimiko-Farmatsevticheskii Zhurnal, Vol. 39, No. 2, pp. 25 – 27, February, 2005.