H—FABP和IMA在急性心肌梗死早期诊断中的敏感性

目的通过测定急性心肌梗死（AMI）心肌损伤标志物脂肪酸结合蛋白（H—FABP）、缺血修饰蛋白（IMA），比较其对AMI早期诊断的价值。方法选取AMI患者51例分别于胸痛发作2h、3h、6h、9h、24h采血测定H—FABP、IMA等指标，采用中华医学会心血管分会2001年12月制订的AMI诊断标准作为金标准，计算几种指标在各时间点的敏感性并相互比较。结果在AMI胸痛发作2h，H—FABP、IMA敏感性分别为62．7％、76．5％；胸痛发作3h，H—FABP、IMA敏感性分别为82．4％、86．3％；胸痛发作6h，H—FABP、IMA敏感性分别为84.3％、80．4％；胸痛发作9h，H—FABP、IMA敏感性分别为64．7％、54．9％；胸痛发作24h，H—FABP、IMA敏感性分别为37．3％、23．5％。结论AMI早期H-FABP及IMA均具有较高的敏感性。

Efficacy of H-FABP and IMA in the early diagnosis of acute myocardial infarction

Objectiv To evaluate the sensitivity of heart-type fatty acid-binding protein （H-FABP） and ischaemia modified albumin （IMA） in acute myocardial infarction （AMI） and compare theirs diagnostic efficacy in early stage AMI. Methods The creteria pulished by Chinese society of cardiology at December, 2001 was taken as the golden standard. H-FABP and IMA were measured in AMI patients at 2 h, 3 h, 6 h, 9 h, 24 h after the onset of chest pain, and the efficacy of these index were evaluated. Results At 2 h after chest pain, the sensitivity rate of H-FABP was 62.7%, the sensitivity of IMA was 76.5%. At 3 h after chest pain, the sensitivity rate of H-FABP was 82.4%, the sensitivity of IMA was 86.3%. At 6 h after chest pain, the sensitivity rate of H-FABP was 84.3%, the sensitivity of IMA was 80.4%. At 9 h after chest pain, the sensitivity rate of H-FABP was 64.7%, the sensitivity of IMA was 54.9%. At 24 h after chest pain, the sensitivity rate of H-FABP was 37.3%, the sensitivity of IMA was 23.5%. Conclusion The sensitivity of H-FABP and IMA is high.