Factors influencing the number of sentinel lymph nodes identified in patients with breast cancer |
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Authors: | Chagpar Anees B,Carlson David J,Laidley Alison L,El-Eid Souzan E,McGlothin Terre Q,Noyes Robert D,Ley Phillip B,Tuttle Todd M,McMasters Kelly M University of Louisville Breast Cancer Sentinel Lymph Node Study |
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Affiliation: | Division of Surgical Oncology, Department of Surgery, University of Louisville, 315 East Broadway, Suite #312, Louisville, KY, USA. anees.chagpar@nortonhealthcare.org |
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Abstract: | BACKGROUND: Although the sentinel lymph node (SLN) is defined as the first node draining a tumor, multiple nodes are often identified. Few SLNs are required for adequate staging; removal of more may be unnecessary. The objective of this study was to determine factors influencing the number of SLN identified. METHODS: The University of Louisville Breast Sentinel Lymph Node Study was used to determine correlates of identifying greater than 4 SLNs by using univariate and multivariate analyses. RESULTS: An SLN was identified in 3,882 of 4,131 patients (94%). The median number of SLN identified was 2 (range 1-18); 90% had < or = 4 SLNs identified. Palpable tumors, surgeon inexperience, and dermal injection were associated with greater than 4 SLNs identified. All 3 of these factors remained significant on multivariate analysis. CONCLUSIONS: Palpable tumors often have greater than 4 SLNs identified, and the use of intradermal injection increases this probability. |
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Keywords: | Breast cancer Sentinel lymph node Identification |
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